Hi, if I may, after reading both articles I understand that long term vit D uptake is deleterious, and even more so in the population with well established Alzeihmer. Also, the quantities and lenght of vit D taken by the participants are not the same between studies. Morever one study is experimental and the other observational. Overall, what I will remember is that vit D can be protective and its dosage should be monitored.
“In conclusion, the results of the current study suggest supplementation of vitamin D may increase the risk of dementia in older adults and increase the risk of mortality in older adults with pre‐existing AD whose blood levels of vitamin D are low. Until our findings are proved otherwise, the use of vitamin D supplementation to prevent dementia should be reconsidered.”
Overview Alzheimer's-Cognition and Vitamin D
https://hlahore.substack.com/p/overview-alzheimers-cognition-and
FACT: Cognitive decline is 19X more likely if low vitamin D
FACT: Dementia is associated with low vitamin D levels.
FACT: Alzheimer’s Dementia 2.3X more likely in elderly if low vitamin D – Dec 2022
FACT: Dementia is associated with low vitamin D - many studies
FACT: Alzheimer's Disease is 4X less likely if high vitamin D
FACT: Every single risk factor listed for Alzheimer's Disease is also a risk factor for low vitamin D levels
FACT: Elderly cognition gets worse as the elderly vitamin D levels get even lower (while in senior homes)
OBSERVATION: Reports of increased vitamin D levels result in improved cognition
OBSERVATION: Alzheimer’s patients 3X more likely to have a malfunctioning vitamin D receptor gene – 2012
OBSERVATION: Alzheimer's Disease has been seen to halt when vitamin D was added.
OBSERVATION: Alzheimer’s is associated with all 7 of the genes which restrict vitamin D
OBSERVATION: 39 vitamin D and Alz. or Cognition intervention trials as of Sept 2018
OBSERVATION: 2 Meta-analysis in 2012 agreed that Alzheimer's Disease. associated with low vitamin D
OBSERVATION: 50X increase in Alzheimer's while decrease in vitamin D
OBSERVATION: Vitamin D reduces Alzheimer’s disease in 11 ways
OBSERVATION: Alzheimer’s cognition improved by 4,000 IU of vitamin D
OBSERVATION: Plaque removed in mice by equiv. of 14,000 IU daily
OBSERVATION: DDT (which decreases Vit D) increases risk of Alzheimer's by up to 3.8X
OBSERVATION: 2% of people have 2 copies of the poor gene reference: Alz Org
OBSERVATION: Genes do not change rapidly enough to account for the huge increase in incidence
FACT: Vitamin D is extremely low cost and has very very few side effects
CONCLUSION: Everyone concerned about cognitive decline or Alzheimer's Disease should take vitamin D
There’s conflicting evidence of vitamin D and Alzheimer’s disease:
https://pubmed.ncbi.nlm.nih.gov/35822270/
Hi, if I may, after reading both articles I understand that long term vit D uptake is deleterious, and even more so in the population with well established Alzeihmer. Also, the quantities and lenght of vit D taken by the participants are not the same between studies. Morever one study is experimental and the other observational. Overall, what I will remember is that vit D can be protective and its dosage should be monitored.
“In conclusion, the results of the current study suggest supplementation of vitamin D may increase the risk of dementia in older adults and increase the risk of mortality in older adults with pre‐existing AD whose blood levels of vitamin D are low. Until our findings are proved otherwise, the use of vitamin D supplementation to prevent dementia should be reconsidered.”