ApoB and You Brain

The one biomarker to get checked

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Today At A Glance:

This one test can literally save you from atherosclerotic cardiovascular disease (ASCVD), a condition that could drastically impede your ability to function at your best. ApoB is a primary component of low-density lipoproteins (LDL), often termed 'bad cholesterol.' It plays a pivotal role in lipid transport and metabolism. Elevated levels of ApoB are directly linked to the development of atherosclerosis, a leading cause of cardiovascular diseases.

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Today’s Newsletter Is Brought To You By Inside Tracker

If you’ve been following me for a while, you’ve heard me talk a lot about the benefits of regular blood testing for health optimization, which is why I love InsideTracker. InsideTracker uses data from your blood, DNA, and fitness trackers to give you personalized and science-backed recommendations on how to feel your best.

The best part?

You can now get your ApoB levels checked with Inside Tracker to give you a clearer picture of your ASCVD risk.

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Neuro Athletes,

I recently reviewed the blood work of a 52-year-old female client with a history of hypertension, and what I found was both shocking and illuminating. Her doctor had never checked her Apolipoprotein B (ApoB) levels, opting instead for the standard cholesterol panel.

This oversight was startling because when I conducted the ApoB test, her levels were at 120 - significantly higher than the ideal range. This revelation brings to light an often-overlooked but crucial aspect of health monitoring, especially in the realm of high performance.

Why is this so important?

Because this one test can literally save you from atherosclerotic cardiovascular disease (ASCVD), a condition that could drastically impede your ability to function at your best.

The best part?

This critical test is now available with Inside Tracker.

In the high-stakes world of Neuro Athletes, where every detail counts, understanding and monitoring ApoB levels is vital. Your brain and body function in unison, demanding not just physical agility but also cognitive excellence. The health of your vascular system, deeply intertwined with your brain health, plays a fundamental role in this environment.

Let’s take a deep dive into the significance of ApoB and why it's essential to keep a close eye on it.

Understanding ApoB

ApoB is a primary component of low-density lipoproteins (LDL), often termed 'bad cholesterol.' It plays a pivotal role in lipid transport and metabolism. Elevated levels of ApoB are directly linked to the development of atherosclerosis, a leading cause of cardiovascular diseases.

Standard laboratory reference ranges for ApoB are population-based, with levels below 80 milligrams per deciliter deemed excellent. However, these ranges are not universally applicable and can vary between labs.

Interestingly, ApoB and its associated lipoproteins have been considered evolutionary relics. Our ancestors needed a system that prioritized having a lot of cholesterol for energy conservation, a necessity that no longer holds true in our energy-abundant present. This evolutionary perspective adds complexity to the role and necessity of ApoB in human physiology.

The Brain-ApoB Connection

The intricate relationship between the brain's health and the integrity of the vascular system is a cornerstone of understanding the broader implications of ApoB levels. Elevated ApoB contributes to the development of atherosclerosis, a condition characterized by the buildup of plaques in the arteries.

This buildup can lead to a significant reduction in blood flow, crucially impacting the brain. Diminished blood supply to the brain not only compromises its function but also markedly increases the risk of cerebrovascular events like strokes. This connection underscores the vital importance of maintaining optimal ApoB levels for those striving to achieve and sustain peak cognitive and physical performance.

The onset of atherosclerosis is not an abrupt event but a gradual process that often begins early in life. ApoB plays a pivotal role in this progression. High levels of ApoB, especially persisting over time, are instrumental in initiating and propelling the development of atherosclerotic plaques.

Therefore, addressing and managing ApoB levels during the early stages of life is critical. By proactively reducing ApoB levels, it is possible to mitigate the risk of developing atherosclerosis, thereby safeguarding the brain's health and functionality. This preventive approach is particularly crucial for individuals who are at an elevated risk due to genetic predisposition or lifestyle factors.

Dietary Influence on ApoB

Diet plays a key role in managing ApoB levels:

1. Insulin Resistance: High triglyceride levels, indicative of insulin resistance, correlate with higher ApoB. Lowering carbohydrate intake, especially refined and starchy carbs, effectively reduces triglycerides and ApoB levels.

2. Saturated Fat: Certain saturated fats can increase cholesterol synthesis and reduce LDL receptors in the liver, leading to increased ApoB levels. However, individual responses to dietary saturated fat vary due to genetic factors.

The Broader Context of Cardiovascular Health

ApoB is a better predictor of atherosclerotic cardiovascular disease than traditional LDL cholesterol measurements. It's not only about the concentration of LDL but also the family of atherogenic lipoproteins, including IDL and VLDL. Measuring ApoB provides a summation of all atherogenic lipoproteins, offering a clearer understanding of cardiovascular health.

The Significance of ApoB in Risk Assessment

The measurement of ApoB can be an indicator of lifelong exposure to atherogenic lipoproteins, similar to assessing the risk of lung cancer in smokers based on their smoking history. Therefore, understanding and managing ApoB levels can be crucial for long-term brain and cardiovascular health.

Genetic Factors and ApoB

Certain genetic predispositions can significantly influence ApoB levels and their impact on cardiovascular health. For example, the LP(a) gene mutation affects a subclass of LDL and is heavily determined by genetics. Those with this mutation may need to be more aggressive in managing their ApoB levels.

Managing ApoB: A Comprehensive Approach

Given the multifaceted nature of ApoB and its impact on health, managing it requires a comprehensive approach. This includes regular monitoring, dietary adjustments, understanding individual genetic predispositions, and considering other cardiovascular risk factors such as hypertension, type 2 diabetes, and smoking habits.

I hope you enjoyed this one team, I would love to know your questions in the comments below.

Until next time,

Louisa x